The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).
نویسندگان
چکیده
The structure and stereochemistry of the cyclohexane substituents of analogues of arterolane (OZ277) had little effect on potency against Plasmodium falciparum in vitro. Weak base functional groups were not required for high antimalarial potency, but they were essential for high antimalarial efficacy in P. berghei-infected mice. Five new ozonides with antimalarial efficacy and ADME profiles superior or equal to that of arterolane were identified.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of medicinal chemistry
دوره 53 1 شماره
صفحات -
تاریخ انتشار 2010